Fig. 2

Functional enrichment analysis of differentially expressed genes in alveolar macrophages from lung tissue samples of severe COVID-19 patients and healthy controls. A Volcano plot depicting differentially expressed genes in Alveolar macrophages between healthy control lung tissue samples (HC group, n = 4) and severe COVID-19 patient lung tissue samples (SC group, n = 4), with red dots to the left of the dashed line representing genes specifically expressed in the HC group and red dots to the right representing genes specifically expressed in the SC group; B KEGG pathway analysis dendrogram of genes specifically expressed in HC and SC groups, categorized into 5 major classes, with each color representing a class; C enrichment analysis of Biological Processes (BP) terms for genes specifically expressed in HC and SC groups; D enrichment analysis of Cellular Component (CC) terms for genes specifically expressed in HC and SC groups; E enrichment analysis of Molecular Function (MF) terms for genes specifically expressed in HC and SC groups