Fig. 5
From: Local delivery of accutox® synergises with immune-checkpoint inhibitors at disrupting tumor growth
AccuTOX® treatment modulates various molecular processes in cancer cells. A The heatmap depicts the upregulated genes associated with mitochondrial oxidative phosphorylation—complex I (Reactome pathways), significantly contributing to the enrichment score in gene set analysis. B Similar to A, this heatmap represents the Reactome pathway “antigen presentation”, highlighting upregulated genes that significantly contribute to the enrichment score from gene set analysis. C The enrichment plot displays the ranking of genes involved in the regulation of TP53 activity against the ranked list of differentially expressed genes in the AccuTOX® group. The genes are ordered from left to right based on decreasing fold change. D The heatmap illustrates the robust repression by AccutOX® of genes associated with the regulation of TP53 activity (Reactome pathways), significantly impacting the expression levels