Fig. 4
From: Local delivery of accutox® synergises with immune-checkpoint inhibitors at disrupting tumor growth
Transcriptomic analysis of AccuTOX®-treated cancer cells. A Schematic diagram depicting the experimental design used for the RNA-seq experiment. B The upset plots illustrate the count of genes that are either commonly or uniquely regulated, either upregulated (upper panel) or downregulated (lower panel), by Accum® or AccuTOX® in EL4 cells when compared to untreated controls. A 5% adjusted p-value was used to determine the differentially expressed genes. C AccuTOX® treatment either induces or downregulates genes associated with ICD. A significance level of 5% was considered based on adjusted p-values