Fig. 3
From: Local delivery of accutox® synergises with immune-checkpoint inhibitors at disrupting tumor growth
Sex-based therapeutic potency and toxicity profiling. A Comparing the potency of the AccuTOX®/PD-1 combination in male and female mice transplanted with B16 tumors. The color code is as follows: male control (black circles), AccuTOX®/PD-1 in male mice (black squares), female control (red circles), AccuTOX®/PD-1 in female mice (red squares). B Kaplan–Meier survival curve for the experiment in panel A. C Weight loss assessment in male mice undergoing AccuTOX®/PD-1 treatment following B16 transplantation. D Same as panel C but on female mice. E Analysis of clinical signs in male mice for the experiments shown in panels A and C. F Analysis of clinical signs in female mice for the experiments shown in panels A and D. For the in vivo experiment shown in panels A-B, n = 10/group. The in vivo experiments were repeated twice