Table 3 Prostate fibrosis imaging– Pros/Cons with respects to the gold standard
Lung Fibrosis Imaging | TRUS Guided Biopsy1 | PROs | Easy to use, Widespread availability, Low-cost, No ionizing radiation |
CONs | Low sensitivity/specificity, Invasive, High false negative rate due to sampling error, Over-diagnosis/treatment of benign peripheral tumours, Operator dependent, Dependent on patient habitus | ||
USE-SE/SWE | PROs | High sensitivity, High negative predictive value, Low-cost, availability, Quantitative, Real time, Readily available, Well tolerated, No ionizing radiation | |
CONs | Operator dependant, Dependent on patient habitus | ||
mpMRI2 | PROs | High sensitivity/specificity, Standardized reporting via PI-RADS, No ionizing radiation | |
CONs | Low diagnostic accuracy, High cost | ||
18Â F-FDG-PET-CT | PROs | Low sensitivity | |
CONs | Use of contrast agent, Use of ionizing radiation, High acquisition time, Low availability, High cost | ||
PSMA-PET-CT | PROs | High sensitivity/specificity/precision | |
CONs | Use of contrast agent, Use of ionizing radiation, High acquisition time, Low availability, High cost | ||
PSMA-PET-MRI | PROs | High soft tissue contrast, Low radiation dose, High sensitivity, No ionizing radiation | |
CONs | Use of contrast agent, High acquisition time, High cost |