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Table 3 Comparison of clinical outcomes with different treatments

From: Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease

Variable

Control group(n = 10)

HBOT group(n = 10)

P value

Week 4

   

CDAI, mean ± SD

197.67 ± 63.71

188.87 ± 51.21

0.738

CRP, mean ± SD, mg/L

30.19 ± 16.00

25.86 ± 22.40

0.875

CRP normalization, n (%)

2 (20%)

5 (50%)

0.160

FC, n (%)

  

0.129

 >1800ug/g

5 (40%)

1 (10%)

 

 200ug/g- 1800ug/g

3 (40%)

4 (40%)

 

 ≤200ug/g

2 (20%)

5 (50%)

 

Clinical response, n (%)

3 (30%)

7(70%)

0.089

Clinical remission, n (%)

2(20%)

5(50%)

0.160

Week8

   

CDAI, mean ± SD

160.52 ± 75.99

146.05 ± 64.34

0.651

CRP, mean ± SD, mg/L

16.08 ± 17.91

15.9 ± 17.52

0.988

CRP normalization, n (%)

7(70%)

7(70%)

1.000

FC, n (%)

  

0.476

 >1800ug/g

1 (10%)

0 (0%)

 

 200ug/g- 1800ug/g

3(30%)

2(20%)

 

 ≤200ug/g

6(60%)

8 (80%)

 

SES-CD, mean ± SD

8.6 ± 5.9

7.2 ± 4.8

0.568

Clinical response, n (%)

6(60%)

8(80%)

0.628

Clinical remission, n (%)

5 (50%)

7 (70%)

0.325

Endoscopic response, n (%)

3 (30%)

3 (30%)

1.000

Endoscopic remission, n (%)

1 (10%)

2(20%)

0.500

  1. Abbreviation CDAI, Crohn’s disease activity index; CRP, C-reactive protein; FC, fecal calprotectin; SES-CD, simple endoscopic score for Crohn’s disease; SD, standard deviation; HBOT, hyperbaric oxygen therapy