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Table 2 Comparison of disease status before and after 10 sessions of HBOT

From: Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease

Variable

Before HBOT(n = 10)

After HBOT(n = 10)

P value

CDAI, mean ± SD

274.87 ± 65.54

221.54 ± 41.89

0.044

Serological examination

   

 WBC, mean ± SD, 109/L

7.38 ± 2.28

7.47 ± 2.30

0.930

 HGB, mean ± SD, g/L

118.40 ± 15.78

108.80 ± 11.71

0.139

 PLT, mean ± SD, 109/L

437.00 ± 167.15

416.80 ± 149.16

0.779

 NLR, mean ± SD

4.47 ± 1.77

3.69 ± 1.10

0.252

 PLR, mean ± SD

291.96 ± 129.79

294.43 ± 80.74

0.959

 ALB, mean ± SD, g/L

29.6 ± 4.3

31.8 ± 5.3

0.322

 D-D, mean ± SD, mg/L

0.21 ± 0.10

0.16 ± 0.07

0.212

 ESR, mean ± SD, mm/h

83.80 ± 19.30

72.40 ± 23.50

0.251

 CRP, mean ± SD, mg/L

80.79 ± 42.05

33.32 ± 18.31

0.004

FC, n (%)

  

0.171

 >1800ug/g

10 (100%)

7 (70%)

 

 200ug/g- 1800ug/g

0 (0%)

2 (20%)

 

 ≤200ug/g

0 (0%)

1 (10%)

 
  1. Abbreviation CDAI, Crohn’s disease activity index; WBC, white blood cell; HGB, hemoglobin; PLT, platelet; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; FC, fecal calprotectin; SES-CD, simple endoscopic score for Crohn’s disease; SD, standard deviation; HBOT, hyperbaric oxygen therapy