Fig. 5

Time-course changes in the variables assessed for endpoints between control group and HBOT group. Graphs show the relative changes of CRP level (A), CDAI (B) and SES-CD (C) at different time points (n = 10 per group). The relative decline rates at week 4 and/or week 8 compared to baseline were tested by Student’s t test (n = 10 per group), ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. CDAI, Crohn’s disease activity index; CRP, C-reactive protein; SES-CD, simple endoscopic score for Crohn’s disease; HBOT, hyperbaric oxygen therapy