Fig. 2

Diversity and composition of gut microbiota in patient with CD before and after HBOT. (A) The boxplot showed the corresponding change of Shannon index in patients with CD before and after HBOT. (B) Permutational multivariate analysis of variance (Adonis) showed that the composition of the gut microbiota was significantly altered among patients after HBOT (P = 0.043). (C) The stack plot of average relative abundance in the group of before HBOT and after HBOT at phylum level. (D) The circle plot exhibited the compositional differences of genera before and after HBOT. (E) The stack plot of each sample showed the taxonomic composition in individuals with CD. CD, Crohn’s disease; HBOT, hyperbaric oxygen therapy