Table 3 Associations between plasma and IgG N-glycan traits and AIH as compared to healthy controls. Logistic regression was performed between AIH (1) and HC (0), including age, sex and their interaction as co-variates. Only significant associations that passed the set log₂ odds ratio threshold (Fig. 2A) are shown. The results of all tests can be found in Supplementary Table 5. To account for multiple testing, p-values have been corrected by the Benjamini-Hochberg procedure using a 5% FDR.

Glycan type

MHy

High mannose to hybrid-type ratio

1.62E-03

0.34 [0.2–0.56]

-1.06

0.27

THy

Total hybrid within total

2.31E-03

2.73 [1.67–4.89]

1.01

0.27

TA2FG0S0

Total fucosylated nongalactosylated nonsialylated A2

2.72E-03

18.55 [4.7-112.74]

2.92

0.81

TA2FS0

Total fucosylated nonsialylated A2

4.41E-03

3.3 [1.76–7.09]

1.19

0.35

Bisection

CB

Of complex-type

5.88E-03

3.78 [1.88–9.35]

1.33

0.41

A2B

Of A2

6.10E-03

3.45 [1.79–7.99]

1.24

0.38

A2SB

Of sialylated A2

1.40E-02

2.76 [1.52–5.89]

1.01

0.34

A2FB

Of fucosylated A2

1.63E-03

3.21 [1.87–6.16]

1.17

0.30

A2FSB

Of fucosylated sialylated A2

2.72E-03

2.72 [1.65–4.96]

1.00

0.28

A2S0B

Of nonsialylated A2

2.23E-03

2.93 [1.74–5.39]

1.08

0.29

A2F0S0B

Of nonfucosylated nonsialylated A2

4.28E-03

2.57 [1.55–4.65]

0.94

0.28

A2F0B

Of nonfucosylated A2

2.12E-02

2.93 [1.49–6.89]

1.08

0.39

A2FS0B

Of nonfucosylated sialylated A2

2.72E-03

2.71 [1.64–4.86]

1.00

0.28

Galactosylation

CG

Of complex-type

2.72E-03

0.06 [0.01–0.22]

-1.19

0.35

A2G

Of A2

2.77E-03

0.18 [0.06–0.42]

-1.70

0.48

A2FG

Of fucosylated A2

1.60E-03

0.28 [0.14–0.49]

-1.27

0.31

A2SG

Of sialylated A2

1.31E-02

0.33 [0.15–0.63]

-1.10

0.37

A2S0G

Of nonsialylated A2

1.60E-03

0.31 [0.17–0.52]

-1.17

0.29

A2FSG

Of fucosylated sialylated A2

2.72E-03

0.38 [0.21–0.62]

-0.97

0.27

A2FS0G

Of fucosylated nonsialylated A2

1.60E-03

0.32 [0.18–0.54]

-1.13

0.28

A2F0S0G

Of nonfucosylated nonsialylated A2

4.28E-03

0.35 [0.18–0.61]

-1.04

0.30

Sialylation

CS

Of complex-type

4.28E-03

0.3 [0.14–0.57]

-1.19

0.35

A4S

Of A4

2.25E-03

2.7 [1.66–4.74]

0.99

0.27

A4GS

Per galactose on A4

1.63E-03

2.88 [1.75–5.16]

1.06

0.27

A4F0GS

Per galactose on nonfucosylated A4

2.72E-03

2.73 [1.64–4.92]

1.00

0.28

IgG glycosylation derived traits

IgG1 bisection

IgG1 bisection

1.63E-03

2.55 [1.63–4.22]

0.94

0.24

IgG1 galactosylation

IgG1 galactosylation

3.47E-05

0.21 [0.11–0.37]

-1.55

0.30

IgG1 sialylation

IgG1 sialylation

1.52E-04

0.28 [0.16–0.45]

-1.29

0.27

IgG1 antennary fucosylation

IgG1 antennary fucosylation

1.62E-03

0.34 [0.19–0.56]

-1.07

0.27

IgG2/3 galactosylation

IgG2/3 galactosylation

1.62E-03

0.35 [0.2–0.58]

-1.04

0.26