Fig. 2

Distribution of DMRs across the whole genome. (A) Circos diagram of the distribution of CpGs and DMRs at the chromosome level. 6 color bars in the heatmap from outside to inside represent the following: EM-seq CpGs density (indigo), EM-seq hyper DMRs (organe), EM-seq hypo DMRs (green), 450K CpGs density (purple), 450K hyper DMRs (red) and 450K hypo DMRs (blue). (B) Linear graph of density of EM-seq(green) and 450K(brown) CpGs on each chromosome. (C) Linear graph of density of EM-seq(green) and 450K(brown) DMRs on each chromosome. Circular symbolize hyper DMR and arrow symbolize hypo DMR. (D) Distribution of specific CpG islands, EM-seq DMRs and 450K DMRs of CCNP on chromosome 19. Gene annotation: promoter region (red);1 to 5 kb region(pink)