Fig. 3

Causal relationships between two potential causal proteins and disease were externally validated. The pQTL data from Ferkingstad et al. were initially externally validated against disease GWAS data from a preliminary study (depicted in deep blue), followed by external validation against the pQTL data from a preliminary study using ankylosing spondylitis GWAS data from FinnGen and iridocyclitis GWAS data from GWAS Catalog (depicted in pale blue). OR, increased risk of disease was expressed as a per-SD increase in plasma protein levels