Fig. 7

Kaplan Meier estimates of significant spatial features. A Higher levels of effector CD4⁺ T cells within tumour regions were associated with better survival. p = 0.013. B) Patients with increased proportions of proliferating tumour cells possessed poorer survival. p = 0.018. C Higher frequency of Tregs interacting with monocytes were associated with poorer survival. p = 0.001. D Higher frequency of Tregs interacting with CD4⁺ T cells were associated with poorer survival. p = 0.059. E Higher levels of effector CD4⁺ T cells within mixed tumour neighbourhoods were associated with better outcome. p = 0.0002. F Higher levels of effector CD4⁺ T cells within mixed tumour neighbourhoods were associated with better outcome. p = 0.071. Median thresholds were applied to categorise groups into high/low. Not adjusted for multiple testing