Fig. 3

The HAVCR2 expression and CD8⁺TILs exhaustion in DLBCL. (a–e Single cell level). a UMAP analysis for different CD8⁺TILs clusters (CD8-1, CD8-2, CD8-3, CD8-4, CD8-5); b the expression of hallmark gene including differentiation, cytotoxicity and IC among different CD8⁺TILs clusters; c–e the cell trajectory analysis of CD8⁺TILs differentiation and the expression of exhaustion state-related characteristic gene (HAVCR2 and TCF7). Blue circle: mainly consists of CD8-5 cells (terminally exhausted state). f (Histology level) the correlation between HAVCR2 and CD8A, CD8B, and IC genes detected by RNA sequencing