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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Cytosine–phosphate–guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis

Fig. 2

Bioinformatics analysis to screen potential targets of CpG-ODNs for treating RKI in cervical cancer. A Venn plot showing the intersection of genes related to "CpG-ODNs" obtained through the CTD database, DEGs in the cervical cancer-related microarray GSE9750 from the GEO database, and genes related to "radiation nephropathy" obtained from the GeneCards database. B STRING database analysis of 21 candidate intersection genes encoding the top 10 proteins with PPI Degree values. C Bubble plot of KEGG enrichment analysis of 21 candidate intersection genes. D Circle plot of KEGG enrichment analysis of 21 candidate intersection genes. E Differential expression data of PARP1 and HMGB1 in microarray GSE9750. Normal = 24, Tumor = 33. F Expression of PARP1 and HMGB1 in TCGA analyzed by Ualcan database. Normal = 3, Tumor = 305. G Regulation of PARP1 by CpG-ODNs in CTD database

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Journal of Translational Medicine

ISSN: 1479-5876

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