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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease

Fig. 6

Schematic diagram of TSLP in the initiation of IgG4-RD. Unknown triggers promote epithelial cells or fibroblasts to release TSLP. TSLP binds to the receptors TSLPR and IL7Ra on B cells, activating JAK-STAT signaling pathway and encouraging the proliferation and IgG4 antibody secretion of B cells. Activated B cells upregulated the expression of OX40L and enhance the differentiation of Tfh cells

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Journal of Translational Medicine

ISSN: 1479-5876

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