Table 2 Features of MAGs in the risk model
No | Gene symbol | Full name | Function | Risk coefficient |
|---|---|---|---|---|
1 | NR3C1 | Nuclear receptor subfamily3 group C member1 | Involved in inflammatory responses, cellular proliferation, and differentiation |  − 0.28597 |
2 | IGFBP3 | Insulin like growth factor binding protein 3 | Prolongs the half-life of IGFs and alters their interaction with cell surface receptors |  − 0.16696 |
3 | RARRES2 | Retinoic acid receptor responder2 | As an adipokine and as an antimicrobial protein with activity against bacteria and fungi |  − 0.14291 |
4 | F5 | Coagulation factor V | Participates with activated coagulation factor X to activate prothrombin to thrombin |  − 0.0961 |
5 | APOC1 | Apolipoprotein C1 | Plays a central role in high density lipoprotein and very low density lipoprotein metabolism |  − 0.07685 |
6 | CSF2RA | Colony stimulating factor 2 receptor subunit alpha | Controls the production, differentiation, and function of granulocytes and macrophages |  − 0.05611 |
7 | ENPP1 | Ectonucleotide Pyrophosphatase/Phosphodiesterase1 | Hydrolyzes nucleoside 5′ triphosphates and diadenosine polyphosphates |  − 0.02214 |
8 | GYG1 | Glycogenin 1 | Associated with glycogen storage disease XV | 0.044962 |
9 | PHKA1 | Phosphorylase kinase regulatory subunit alpha1 | Associated with glycogen storage disease type 9D, known as X-linked muscle glycogenosis | 0.069351 |
10 | CPT1A | Carnitine palmitoyltransferase 1A | Key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane | 0.075212 |
11 | PDK4 | Pyruvate dehydrogenase kinase 4 | Involved in regulation of glucose metabolism | 0.076723 |
12 | CLOCK | Clock circadian regulator | Plays a central role in the regulation of circadian rhythms | 0.085885 |
13 | CTH | Cystathionine gamma-lyase | Converts cystathione derived from methionine into cysteine | 0.108709 |
14 | PLTP | Phospholipid transfer protein | Involved in regulating the size of HDL particles and cholesterol metabolism | 0.160136 |